- General questions
- FAQ's
- 1. My doctor told me I have Kallmann's syndrome. What does this mean ?
- 2. When was Kallmann's syndrome first discovered ?
- 3. What does an endocrinologist do?
- 4. I have heard of "hormones" before, but what are they ?
- 5. What and where are my hypothalamus and pituitary gland ?
- 6. What happens during normal puberty ?
- 7. As a teenager, I didn't go through puberty at all. Why ?
- 8. How good are my chances of becoming a parent ?
- 9. Why did my doctor ask me whether or not I had a sense of smell ?
- 10. Why don't I have a sense of smell ?
- 11. What has my absent sense of smell got to do with absent puberty ?
- 12. Others have said that I have long arms and legs. Can this be true ?
- 13. Will I develop 'brittle bone disease' ?
- 14. What other characteristics of Kallmann's syndrome are there ?
- 15. What is the difference between Kallmann syndrome and Klinefelter syndrome ?
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Kallmann's Syndrome Information
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Medical Warning
Information on this site is provided by people with personal experience of Kallmann's syndrome. Symptoms and appropriate treatments are different for different people. You should not treat anything on this site as a substitute for advice from a trained medical professional.
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© 2008 Neil Smith
10. Why don't I have a sense of smell ?
You may recall from the answer to Question 5 that since you have Kallmann's syndrome, most of, if not all of your olfactory system (which is needed for a normal sense of smell) is defective. Let us first take a look at the normal olfactory system.
The normal olfactory system
In Figure 9, the olfactory system consists of five main components: the olfactory hairs or nerve fibres (item 1), the olfactory cells (item 2), the previously mentioned olfactory bulbs (item 3) and special nerve cells (item 4) found in the olfactory tracts (item 5). The nasal cavity is a space in the nose that lies just above the roof of the mouth. The olfactory hairs are normally found at the top of the nasal cavity, ready to detect a smell coming through the nostril. The detected smell is converted into a tiny electrical signal by the olfactory cells anchored to the olfactory bulb and sent through the nerve cells or neurons along the olfactory tract to those regions of the brain where it can be identified and recognised as a particular smell. There is one olfactory bulb and tract for each nostril.
Olfactory system
The absent olfactory system and Kallmann's syndrome
This was first documented by Aureliano Maestre de San Juan in 1856 (see answer to Question 2). In Kallmann's syndrome, it is mainly the olfactory bulbs and tracts which are either partially formed or missing altogether. However, some olfactory cells may well be present at the top of the nasal cavity, but they are useless since there is no communication link between them and the brain. Consequently, somebody with Kallmann's syndrome finds it impossible to identify a particular smell.

